◀ Back to EPHB2

EPHB2 — HMOX1

Text-mined interactions from Literome

Chen et al., Cell Mol Biol Incl Cyto Enzymol 2000 : ERK and p38 inhibitors also suppressed induction of HO-1 by SNAP and GSNO
Zhang et al., Am J Physiol Lung Cell Mol Physiol 2002 (Lung Diseases...) : We also demonstrate that HO-1 gene transcription after A-R involves ERK , JNK, and p38 MAPK pathways
Liu et al., Life Sci 2004 (MAP Kinase Signaling System) : Although 15d-PGJ ( 2 ) significantly activated the MAPKs of JNK and ERK, the activation of JNK and ERK did not contribute to the induction of HO-1 as determined using transfection of dominant negative plasmids and MAPKs inhibitors
Chen et al., J Cell Biochem 2004 (Carcinoma, Papillary...) : The induced levels of HO-1 and p21 were significantly reduced by p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular regulated kinase (ERK) inhibitors
Gong et al., Arch Biochem Biophys 2004 (Hepatoblastoma) : Both ERK and p38 pathways play an important role in DAS induced Nrf2 nuclear translocation and ho-1 gene activation
Anwar et al., Free Radic Biol Med 2005 (Arteriosclerosis...) : These findings demonstrate for the first time that activation of PKC, p38 ( MAPK ), JNK, ERK1/2 , and Nrf2 by oxidized LDL in human SMC leads to HO-1 induction, constituting an adaptive response against oxidative injury that can be ameliorated by vitamin C
Iles et al., Free Radic Biol Med 2005 : Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated ERK phosphorylation, c-Fos protein induction, AP-1 binding, and HO-1 protein induction , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA ... This suggests that ERK is involved in the increase in HO-1 through regulation of translation rather than transcription
Watanabe et al., Am J Pathol 2006 : Inhibition of ERK activation with MEK inhibitors ( PD98059 or U0126 ) diminished induction of the antioxidant enzyme heme oxygenase-1
Oh et al., Free Radic Biol Med 2006 : Both H ( 2 ) S solution prepared by bubbling pure H ( 2 ) S gas and NaSH, a H(2)S donor, dose dependently induced HO-1 expression through the activation of the extracellular signal regulated kinase ( ERK )
Xu et al., Mol Cancer Ther 2006 (Prostatic Neoplasms) : Activation of ERK and JNK signaling also resulted in the elevation of ARE activity and HO-1 expression
Woo et al., J Biol Chem 2006 (Inflammation) : We found that overexpression of HO-1 and [ Ru ( CO ) ( 3 ) Cl(2) ] ( 2 ), a carbon monoxide ( CO ) -releasing compound, increased not only ERK5 kinase activity, but also its transcriptional activity measured by luciferase assay with the transfection of the Gal4-ERK5 reporter gene
Cooper et al., Toxicol Appl Pharmacol 2007 : These findings suggest that the ERK/MAPK activation is necessary but not sufficient for optimal arsenite stimulated HO-1 induction
Kim et al., Ann N Y Acad Sci 2006 : To determine whether the induction of HO-1 is responsible for ERK1/2 activation, the HO-1 inhibitor, zinc protoporphyrin ( ZnPP ) was used
Sun et al., Life Sci 2008 (MAP Kinase Signaling System) : YS 49 induced HO-1 protein production in a dose-and time dependent manner in VSMCs. Treatment with YS 49 significantly and dose-dependently inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or ERK1/2
Hsu et al., J Cell Physiol 2008 : Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2 , p38alpha, and PI3-kinase
Hwang et al., Toxicol Appl Pharmacol 2008 : Metallothionein-III protects against 6-hydroxydopamine induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2 dependent manner
Rémy et al., J Immunol 2009 : HO-1 and CO inhibited LPS induced activation of the IFN regulatory factor 3 pathway and their effects were independent of p38, ERK , and JNK MAPK
Takagi et al., J Pharmacol Exp Ther 2009 : Phosphorylation of ERK and Nrf2, activation and nuclear translocation of Nrf2, and oxidation of Keap1 are all involved in the lansoprazole induced HO-1 up-regulation
Goven et al., FEBS Lett 2009 (Emphysema...) : These results suggest that ERK ( 1/2 ) and JNK are involved in CS-induced biphasic HO-1 expression by a specific regulation of Nrf2/Keap1-Bach1
Park et al., Biochimie 2010 (Colonic Neoplasms) : The pharmacological inhibition of ERK and p38 MAPK inhibited rottlerin induced HO-1 up-regulation
Chen et al., J Agric Food Chem 2010 : Besides, ERK1/2 inhibitor significantly inhibited hesperidin mediated HO-1 upregulation and Nrf2 nuclear translocation
Li et al., Acta Pharmacol Sin 2010 : By inhibiting HO-1 activity with ZnPP IX, the inhibitive effect of neferine on ERK1/2 phosphorylation was significantly attenuated
Lu et al., Biol Psychiatry 2010 (Inflammation) : In addition, DHA caused AKT and ERK activation in a time dependent manner, and the DHA induced HO-1 upregulation could be attenuated by PI-3 kinase/AKT and MEK/ERK inhibitors
Chen et al., Food Chem Toxicol 2010 : Western blot showed that hesperidin facilitated ERK/MAPK phosphorylation which appeared to be responsible for nuclear translocation of Nrf2, thereby inducing cytoprotective heme oxygenase-1 (HO-1) expression
Yang et al., Free Radic Biol Med 2011 : These results suggest the involvement of ERK2 and Nrf2 in the induction of HO-1 and GCLC by butein
Huang et al., Arch Toxicol 2013 : Both ERK2 and Nrf2 siRNAs attenuated chrysin induced HO-1 , GCLC, and GCLM protein expression
Chen et al., J Huazhong Univ Sci Technolog Med Sci 2012 : Moreover, ß-PGG induced Nrf2 nuclear translocation, which was found to be upstream of ß-PGG induced HO-1 expression, and the activation of ERK and Akt, a pathway that is involved in ß-PGG induced Nrf2 nuclear translocation, HO-1 expression and neuroprotection
Lin et al., PloS one 2012 (Neurodegenerative Diseases) : Moreover, desipramine induces HO-1 expression through activation of ERK and JNK signaling pathways
Chien et al., Free Radic Biol Med 2013 (Genetic Predisposition to Disease...) : Akt and ERK are involved in HO-1 induction after oxidative stress
Gu et al., International journal of medical sciences 2013 (MAP Kinase Signaling System...) : Additionally, the potential roles of ERK , p 38 MAPK and JNK in the regulation of propofol induced endogenous HO-1 expression in SH-SY5Y cells were estimated by Western blotting assays