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DOCK2 — RAC3

Text-mined interactions from Literome

Sanui et al., Immunity 2003 : We show here that DOCK2 is essential for TCR mediated Rac activation and immunological synapse formation
Jiang et al., J Exp Med 2005 : In addition, we found that DOCK2 is critical for CD28 mediated Rac activation and is required for the full activation of alloreactive T cells
Kunisaki et al., J Cell Biol 2006 : DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
Nishikimi et al., Science 2009 : In neutrophils, Rac activation is primarily mediated by DOCK2 , an atypical guanine nucleotide exchange factor
Namekata et al., Proc Natl Acad Sci U S A 2010 : BDNF induces axonal sprouting through Dock dependent Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011 : Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis ( DOCK ) nucleotide exchange factors
Ippagunta et al., Nat Immunol 2011 : Thus, ASC shapes adaptive immunity independently of inflammasomes by modulating Dock2 dependent Rac activation and actin polymerization in DCs and lymphocytes