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PTGS2 — SETD2

Text-mined interactions from Literome

Csiki et al., Cancer Res 2006 (Carcinoma, Non-Small-Cell Lung...) : In this study, we sought to determine the role of HIF-1 in the induction of COX-2 expression during hypoxia
Kaidi et al., Cancer Res 2006 (Colorectal Neoplasms...) : Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia ... This study identifies COX-2 as a direct target for HIF-1 in colorectal tumor cells
Gu et al., Zhongguo Fei Ai Za Zhi 2011 (Adenocarcinoma...) : The overexpression of HIF-1a may induce the overexpression of COX-2 , and is non correlated with expression of E-cadherin
Zuloaga et al., Am J Physiol Heart Circ Physiol 2011 : Since hypoxia inducible factor-1a (HIF-1a) activation can lead to COX-2 production, this study determined the influence of DHT on HIF-1a and COX-2 following hypoxia or hypoxia with glucose deprivation (HGD) in the cerebral vasculature
Wu et al., J Pathol 2011 (Endometriosis) : In contrast, forced expression of DUSP2 under hypoxia abolishes HIF-1a induced ERK phosphorylation and COX-2 expression
Hari Kishore et al., Mol Endocrinol 2012 : We also show that activation of HIF-1a induced cyclooxygenase-2 and that prostaglandin E ( 2 ) repressed MiTF-CX
Garufi et al., PloS one 2012 : Here, zinc supplementation to HIPK2 depleted cells inhibited HIF-1 induced COX-2 expression and PGE ( 2 ) /VEGF production ... THESE FINDINGS SHOW THAT : 1 ) HIPK2 knockdown induced COX-2 upregulation, mostly depending on HIF-1 activity ; 2 ) zinc treatment downregulated HIF-1 induced COX-2 and inhibited PGE ( 2 ) /VEGF production ; and 3 ) zinc treatment of HIPK2 depleted cells restored DCs maturation