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CXCL12 — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SRC → CXCL12 (increases, CXCL12 Activity) Okabe et al., J Hematother Stem Cell Res 2002
  Evidence: Src kinase was phosphorylated and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activated in a time-related fashion after SDF-1 stimulation.
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr)(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) (translocation, collaborate)
  
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → dynamin gtpase (DNM1) (translocation, collaborate)
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → RAS (HRAS) (modification, activates)
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → None (modification, activates)
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → None (modification, activates)
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → dynamin gtpase (DNM1) (modification, activates)
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → SRC/Hck/c-Fgr (FGR/HCK/SRC) (modification, collaborate)
  
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1) (modification, collaborate)
  
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: SRC/Hck/c-Fgr (FGR/HCK/SRC) → Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1) (modification, collaborate)
  
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Arrestin/SRC/Hck/c-Fgr complex (ARRB1-FGR_HCK_SRC) → Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr)(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) (degradation, collaborate)
  
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Ottoson et al., J Immunol 2001 : Stimulation of Jurkat T cells with CXCL12 also resulted in ZAP-70 dependent tyrosine phosphorylation of the Src homology 2 domain containing leukocyte protein of 76 kDa ( SLP-76 ) adapter protein
Uchida et al., Exp Cell Res 2003 (Carcinoma, Squamous Cell...) : SDF-1alpha also activated Src family kinases (SFKs) , and its inhibitor PP1 diminished the SDF-1alpha induced chemotaxis and activation of both ERK1/2 and Akt/PKB
Kayali et al., J Cell Biol 2003 (Disease Models, Animal) : We show that SDF-1alpha stimulates the phosphorylation of Akt, mitogen activated protein kinase, and Src in pancreatic duct cells
Lin et al., J Immunol 2006 : Thrombin induced increase in IL-8/CXCL8-Luc activity was inhibited by the dominant negative mutant of c-Src and the cells transfected with the kappaB site mutation of the IL-8/CXCL8 construct
Petrai et al., Int J Biochem Cell Biol 2008 : In cells expressing CXCR3-A, CXCL10 ( IP-10 ) at nanomolar concentrations induced activation of ERK, Akt, and Src , as previously described in human vascular pericytes