◀ Back to ATR
ATR — RAD9A
Pathways - manually collected, often from reviews:
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
Hus1/Rad1/Rad9/Rad17 complex (HUS1-RAD1-RAD9A-RAD17)
(modification, activates)
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, collaborate)
Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
CHK1 (CHEK1)
(modification, collaborate)
Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
→
CHK1 (CHEK1)
(modification, collaborate)
Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
YWHAZ (YWHAZ)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
(modification, activates)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
YWHAZ (YWHAZ)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, activates)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
CHK1 (CHEK1)
(modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CHK1 (CHEK1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
→
RPA/ATR/ATRIP complex (RPA1-RPA2-ATR-ATRIP)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Medhurst et al., J Cell Sci 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
→
RPA/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Medhurst et al., J Cell Sci 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP complex (RPA1-RPA2-ATR-ATRIP)
→
RPA/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Medhurst et al., J Cell Sci 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CDC6 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CDC6)
→
CDC6 (CDC6)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CDC6 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CDC6)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CDC6 (CDC6)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
TIMELESS/TIPIN complex (TIMELESS-TIPIN)
(modification, collaborate)
Unsal-Kaçmaz et al., Mol Cell Biol 2007, Kemp et al., J Biol Chem 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Unsal-Kaçmaz et al., Mol Cell Biol 2007, Kemp et al., J Biol Chem 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
TIMELESS/TIPIN complex (TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Unsal-Kaçmaz et al., Mol Cell Biol 2007, Kemp et al., J Biol Chem 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CLASPIN (CLSPN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
(modification, collaborate)
Wang et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CLASPIN (CLSPN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Wang et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Wang et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
TopBP1 (TOPBP1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Kumagai et al., Cell 2006, Ball et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Mordes et al., Genes Dev 2008, Medhurst et al., J Cell Sci 2008, Vassin et al., J Cell Sci 2009, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
TopBP1 (TOPBP1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Kumagai et al., Cell 2006, Ball et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Mordes et al., Genes Dev 2008, Medhurst et al., J Cell Sci 2008, Vassin et al., J Cell Sci 2009, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Kumagai et al., Cell 2006, Ball et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Mordes et al., Genes Dev 2008, Medhurst et al., J Cell Sci 2008, Vassin et al., J Cell Sci 2009, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
SMARCAL1 (SMARCAL1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Bansbach et al., Genes Dev 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
SMARCAL1 (SMARCAL1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/SMARCAL1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-SMARCAL1)
(modification, collaborate)
Bansbach et al., Genes Dev 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/SMARCAL1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-SMARCAL1)
(modification, collaborate)
Bansbach et al., Genes Dev 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
CEP164 (CEP164)
(modification, collaborate)
Sivasubramaniam et al., Genes Dev 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Sivasubramaniam et al., Genes Dev 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CEP164 (CEP164)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Sivasubramaniam et al., Genes Dev 2008
Evidence: mutant phenotype, assay, physical interaction
-
WikiPathways ATR Signaling:
RPA1/RPA1/RPA1/RPA1/RPA1/ATR/ATRIP
→
RAD9B/RAD1/RAD9A/HUS1/RPA1/RPA1/RPA1/RPA1/RPA1/ATR/ATRIP/TOPBP1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lee et al., J Biol Chem 2007
:
These findings suggest that interaction of the
9-1-1 complex with the BRCT I-II region of TopBP1 is
necessary for binding of ATR-ATRIP to the ATR activating domain of TopBP1 and the ensuing activation of
ATR
Xu et al., Mol Cell Biol 2008
:
Disruption of the
RAD9-RPA interaction also
impairs ATR signaling to CHK1 and causes hypersensitivity to both DNA damage and replication stress