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CD86 — IFNG

Text-mined interactions from Literome

Liu et al., Scand J Immunol 1999 (Lupus Erythematosus, Systemic) : Interferon-gamma (IFN-gamma) increased both CD80 and CD86 expression on monocytes from both SLE patients and normal groups, albeit less significantly in the former than in the latter, i.e. CD80 : 142.84+/-65.99 % versus 226.08+/-78.90 %, P < 0.05 ; and CD86 : 72.55+/-74.23 % versus 153.99+/-94.14 %, P < 0.05, when expressed as percentage modulation ... We concluded that CD80 and CD86 were differentially expressed and modulated on monocytes and the defective IFN-gamma induced up-regulation of CD80 and CD86 expression on SLE monocytes might be a factor in the pathogenesis of SLE
Frucht et al., Clin Immunol 1999 (Mycobacterium avium-intracellulare Infection) : CD86 blockade caused a greater than 50 % reduction in both normal and familial patient interferon-gamma production, implying that a majority of residual familial patient costimulation required this pathway
Subauste et al., J Immunol 2000 : IL-12 independent IFN-gamma production required CD80/CD86-CD28 interaction and, to a lesser extent, CD40-CD40L signaling
Jeannin et al., Immunity 2000 : CD86deltaTM also induces IFNgamma production by virus-specific CD8+ memory human T cells stimulated with the Flu M1 peptide
Magistrelli et al., Biochem Biophys Res Commun 2001 : The activation of monocytes by IFNgamma (i) induces the preferential expression of the transcript encoding for the membrane form and ( ii ) increases the expression of CD86 and of the accessory molecules CD40, CD49d and CD54
Matsumura et al., Ann Rheum Dis 2001 (Lymphadenitis...) : Interferon gamma (IFNgamma) consistently up regulated levels of CD80 and CD86 ... IFNgamma consistently up regulated CD86 expression ... Salivary ductal cells in patients with SS can express CD80 and CD86 costimulatory molecules in response to IFNgamma
Blazevic et al., J Clin Immunol 2001 : Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-specific T cell proliferation, interleukin (IL)-2 and interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Ponte-Sucre et al., Immunopharmacol Immunotoxicol 2001 (Leishmaniasis) : We provide evidence that in BALB/c murine macrophages, GLIB induced a decrease in the interferon-gamma stimulated expression of major histocompatibility complex class II molecules and the co-stimulatory molecule CD86 ( B7-2 )
Tsunawaki et al., J Rheumatol 2002 (Sjogren's Syndrome) : Interferon-gamma (IFN-gamma) induced the cultured salivary gland epithelial cells to express HLA class I antigens, HLA-DR antigens, CD80, and ICAM-1, while tumor necrosis factor-alpha (TNF-alpha) induced the expression of HLA class I antigens, CD80, CD86 , and VCAM
Sindhi et al., J Immunol Methods 2003 : PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ), ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2, TNF-alpha, and IFN-gamma was inhibited by CsA, and minimally by SRL, and ( 2 ) the two agents inhibited pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and CD95, but not CD86 ( ICAM-1, Fas antigen, and B7.2 ), synergistically
Rutkowski et al., Arch Immunol Ther Exp (Warsz) 2003 (Asthma) : CD80 and CD86 expression on LPS stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma
Shi et al., Zhonghua Yi Xue Za Zhi 2003 : When instilled intratracheally in ovalbumin sensitized recipient mice, these antigen loaded eosinophils migrated into draining paratracheal lymph nodes primed Th2 cells in vivo for IL-4, IL-5 and IL-13, but not IFN-gamma , production during the in vitro culture that was also CD80- and CD86 dependent
Shi et al., Allergy 2004 : When instilled intratracheally in sensitized recipient mice, airway eosinophils migrated into draining paratracheal lymph nodes primed Th2 cells in vivo for IL-4, IL-5, and IL-13, but not IFN-gamma , production during the in vitro culture that was also CD80- and CD86 dependent
Gutzmer et al., Immunology 2004 : After up-regulation of the C3aR by IFN-alpha+ IFN-gamma , C3a significantly up-regulated the surface expression of CD54, CD83 and CD86 , but not of CD40, CD80 or human leucocyte antigen ( HLA ) -DR. C3a had no effect on the production of interleukin (IL)-10 or IL-12p70, or on the capacity of MoDC to stimulate autologous T-cell proliferation
Xie et al., Chin Med J (Engl) 2005 : When instilled intratracheally in sensitized recipient mice, airway EOSs primed lung Th2 cells in vivo for interleukin-4, interleukin-5 and interleukin-13, but not interferon-gamma , production during the in vitro culture that was also CD80- and CD86 dependent
Neves et al., Cancer Immunol Immunother 2005 (Carcinoma, Renal Cell...) : Dendritic cells derived from metastatic cancer patients vaccinated with allogeneic dendritic cell-autologous tumor cell hybrids express more CD86 and induce higher levels of interferon-gamma in mixed lymphocyte reactions
Nakahara et al., Clin Exp Immunol 2005 (Neoplasms) : Our results show that IFN-gamma , but not IL-1beta, augmented the surface expression of CD80, CD83 and CD86 molecules without inducing IL-12 production from DCs
Makino et al., Cell Immunol 2005 (Leprosy) : The DC-mediated IFN-gamma production was dependent on the expression of MHC, CD86 , and MMP-II antigens
Li et al., J Immunol 2006 (Glomerulonephritis) : Following i.p. immunization, CD86 , but not CD80, promotes early Ag-specific TCR-transgenic DO11.10 CD4+ cell proliferation and IFN-gamma production, suggesting that CD100 expression enables full expression of CD86 and consequent CD4+ cell activation
Yadav et al., J Leukoc Biol 2006 : IFN-gamma production was also shown to be important for enhanced T-bet gene expression but not important for up-regulation of CD86
Muralimohan et al., Cell Immunol 2006 : Nonetheless, pDCs strictly required IFNgamma for upregulation of CD86 and CD40, but cDCs did not depend upon IFNgamma for activation
Steers et al., Vaccine 2008 : L ( LA ) enhanced the surface expression of MHC class I, class II, CD80, and CD86 molecules, induced the secretion of IFN-gamma , IL-12p40, TNF-alpha and IL-10, and caused a shift in the proteasome profile from constitutive to immunoproteasomes as observed by the induction of beta2i, beta5i, PA28alpha, and PA28beta subunits
Nguyen et al., Cytotherapy 2008 : At a contaminating concentration of 5 Plt/MO, matured DC showed the highest expression of HLA-DR, CD80 and CD86 , inducing a strong T-cell proliferation with high production of IL-4 and interferon-gamma
Izawa et al., Biochem Biophys Res Commun 2010 : Moreover, P-gp blockade, compared to controls, attenuated intragraft expression of CD3 and CD80, but not CD86 , and inhibited IFN-gamma and IL-4 production ( P < 0.05 )
Petro et al., Immunol Invest 1995 : Production of IFN-gamma was significantly blocked by either anti-CD80 and anti-CD86
Ozawa et al., Eur J Immunol 1996 : Based on the recently reported effect of interferon (IFN)-gamma and interleukin (IL-)-10 on the expression of CD80 and CD86 by LC, we examined the effects of these cytokines on the expression of CD54 ( intercellular adhesion molecule-1 ) and CD40 in addition to CD80 and CD86 on LC, and correlated the expression of each co-stimulatory molecule with antigen presentation for a Th1 clone by cultured LC (cLC) treated with these cytokines
Yokozeki et al., Br J Dermatol 1997 : Interferon-gamma differentially regulates CD80 ( B7-1 ) and CD86 ( B7-2/B70 ) expression on human Langerhans cells ... These data indicate that the CD80 and CD86 expression of human LCs may be differently regulated by IFN-gamma
Subauste et al., J Immunol 1998 : Moreover, proliferation and IFN-gamma production by CD4+ CD45RA+ T cells from unexposed individuals were dependent on both CD80 and CD86