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EPHB2 — WNK1

Text-mined interactions from Literome

Xu et al., J Biol Chem 2004 : WNK1 activates ERK5 by an MEKK2/3 dependent mechanism ... Here we report that overexpression of WNK1 led to increased activity of cotransfected ERK5 in HEK293 cells ... Expression of dominant negative mutants of MEKK2 and MEKK3 also blocked activation of ERK5 by WNK1 ... Finally, ERK5 activation by epidermal growth factor was attenuated by suppression of WNK1 expression using small interfering RNA
Garaude et al., J Immunol 2006 (Leukemia) : shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes
Zheng et al., Chin J Integr Med 2010 (Brain Ischemia...) : Furthermore, WNK inhibited GRK2 translocation from cytosol to the membrane ( at 20 mg/kg ) and reduced ERK1/2 phosphorylation and MMP-9 expression in cortical microvessels
Xu et al., J Biol Chem 2012 : It is surprising that LNT-S enhanced LPS induced NF-?B p65 nuclear translocation and NF-?B luciferase activity, but severely inhibited the phosphorylation of JNK1/2 and ERK1/2
Li et al., J Biomed Biotechnol 2012 (Atherosclerosis) : The plasmin induced CCL20 expression was dependent on Akt- and ERK1/2 mediated phosphorylation of I?Ba on Ser32/36 and of p65 on Ser276, whereas p38 MAPK appeared to be dispensable