Gene interactions and pathways from curated databases and text-mining

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MAP3K1 — SMAD3

Text-mined interactions from Literome

Brown et al., J Biol Chem 1999 : Activation of Smad2 by active MEKK-1 results in enhanced Smad2-Smad4 interactions, nuclear localization of Smad2 and Smad4, and the stimulation of Smad protein-transcriptional coactivator interactions in endothelial cells
Dennler et al., J Biol Chem 2000 : Overexpression of constitutively active MEKK1 or MKK4 mutants stabilizes the physical interaction between Smad3 and c-Jun, whereas dominant negative mutants inhibit this interaction