Herndon et al., J Immunol 2001
:
ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28
Mertens et al., PLoS Pathog 2009
(Abdominal Abscess) :
In CD8 ( + ) CD28 ( - ) T cells, Sp1 enhances Zap-70 phosphorylation and increasingly involves NF-kappaB which ultimately results in protection versus apoptosis and cell death and promotes survival and accumulation of the CD8 ( + ) CD28 ( - ) population