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GDI1 — RAC2

Pathways - manually collected, often from reviews:

• Reactome Reaction: RAC2 → GDI1 (reaction) Scheffzek et al., Nat Struct Biol 2000, Hoffman et al., Cell 2000, Robbe et al., J Biol Chem 2003, Hart et al., Science 1992, Sun et al., J Biol Chem 2004, DerMardirossian et al., Trends Cell Biol 2005, Bächner et al., Hum Mol Genet 1995, Adra et al., Proc Natl Acad Sci U S A 1997, Gosser et al., Nature 1997
• Reactome Reaction: RAC2 → GDI1 (indirect_complex) Scheffzek et al., Nat Struct Biol 2000, Hoffman et al., Cell 2000, Hart et al., Science 1992, Sun et al., J Biol Chem 2004, DerMardirossian et al., Trends Cell Biol 2005, Bächner et al., Hum Mol Genet 1995, Adra et al., Proc Natl Acad Sci U S A 1997, Gosser et al., Nature 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: RAC2 — GDI1 (in vivo) Gorvel et al., FEBS Lett 1998*
• IRef Hprd Interaction: RAC2 — GDI1 (in vitro) Gorvel et al., FEBS Lett 1998*
• IRef Ophid Interaction: RAC2 — GDI1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Di-Poï et al., Biochemistry 2001 : These data suggest that Rho-GDI stabilizes Rac in an active conformation, even in the GDP bound state, and presents it to its effector, the p67phox component of the NADPH oxidase
Groysman et al., J Biol Chem 2002 : Surprisingly, Vav1 associates with Ly-GDI , a hematopoietic cell-specific guanine nucleotide dissociation inhibitor of Rac