Utreras et al., J Biol Chem 2009
(Pain) :
Our results indicate that tumor necrosis factor-alpha (TNF-alpha) activates p35 promoter activity in a dose- and time dependent manner and concomitantly up-regulates Cdk5 activity
Beidler et al., J Biol Chem 1995
:
Given that p35 inhibits both TNF and Fas killing, along with previous reports of its ability to block developmental, viral, and x-irradiation induced cell death, the present results indicate that TNF- and Fas mediated apoptotic pathways must have components in common with these highly conserved death programs