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SLC9A3 — TNF
Text-mined interactions from Literome
Khan et al., Nephron 2002
(Body Weight...) :
Selective induction of NHE-3 and TNF-alpha, and their reversal by cox-2 inhibition, suggest a cox-2 dependent regulation of
NHE-3 , which possibly
involves TNF-alpha released from the site of inflammation and not from the kidney in colitis
Amin et al., Am J Physiol Cell Physiol 2006
:
IFN-gamma and
TNF-alpha regulate human
NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1 ... Our data indicate that IFN-gamma and
TNF-alpha may
repress the
NHE3 promoter activity in C2BBe1 cells by PKA mediated phosphorylation of Sp1 and Sp3 transcription factors
Siddique et al., Scand J Gastroenterol 2009
(Colitis, Ulcerative...) :
These findings suggest a
role of
TNF-a in the regulation of
NHE-3 expression in IBD