Ohta et al., Cancer Res 2005
(Stomach Neoplasms) :
The disruption of glioma associated oncogene 1 (Gli1) by small interfering RNA induced an increase in p21/cyclin dependent kinase interacting protein 1 ( CIP1 ), interfered with the G1-S transition, and suppressed cell proliferation
Rizvi et al., Cancer Res 2010
(Adenocarcinoma...) :
To further understand the regulation of CDK2 by GLI1, both pharmacologic and RNAi mediated approaches show that GLI1 is a transcriptional activator of CDK2 , and this regulation occurs independent of Smoothened, the central transducer of the Hedgehog canonical pathway