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CXCR4 — SETD2

Text-mined interactions from Literome

Phillips et al., J Biol Chem 2005 (Anoxia...) : A molecular analysis of these events indicated that augmented CXCR4 expression was regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signal transduction pathway, activation of hypoxia inducible factor (HIF) 1alpha, and ultimately HIF-1 dependent transcription of the CXCR4 gene
Hoenig et al., Curr Mol Med 2008 (Ischemia...) : HIF-1 , the master regulator or neovascularization, regulates the expression of vascular endothelial growth factor ( VEGF ), stromal cell derived factor-1 (SDF-1) and CXC chemokine Receptor-4 (CXCR4)
Melchionna et al., Cardiovasc Res 2010 (Acidosis...) : The inhibition of CXCR4 expression occurred transcriptionally and was hypoxia-inducible factor (HIF)-1alpha dependent as demonstrated by both HIF-1alpha and HIF-1alpha dominant negative overexpression, by HIF-1alpha silencing, and by targeted mutation of the -29 to -25 hypoxia response element ( HRE ) in the -357/-59 CXCR4 promoter fragment
Sun et al., Molecular cancer 2010 (Chondrosarcoma...) : The present study determined the effect of hypoxia and specifically HIF-1a on expression of CXCR4 and MMP1 and their role in chondrosarcoma cell invasion ... Hypoxia and specifically HIF-1a increased CXCR4 and MMP1 expression in JJ cell line and chondrosarcoma invasion in vitro ... Chondrosarcoma cell invasion is increased by hypoxia induced expression of CXCR4 and MMP1 and is mediated by HIF-1a and ERK
Sinha et al., Cell Signal 2011 (Glioblastoma...) : Thus HIF-1a positively and negatively regulates SOCS3 and CXCR4 expression respectively, in glioma cells