Nascimento et al., Eur J Pharmacol 2012
:
In conclusion, the mitogenic effect of relaxin in Sertoli cell involves coupling to G ( i ) and activation of both MEK/ERK1/2 and PI3K/AKT pathways
Ahmad et al., Mol Cell Endocrinol 2012
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Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K, Akt, ERK and PKC-? and the transcription factors Elk-1, c-fos and, to a lesser extent, NF-?B are involved in relaxin 's induction of MMP-9