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IL6 — UTP6
Text-mined interactions from Literome
Abbott et al., Mol Pharmacol 2000
:
IL-6 mRNA
induction by
UTP is more rapid and transient then that caused by IL-1beta stimulation and is partially blocked by cyclosporin A or by expression of a trans-dominant NFAT inhibitor ... However, trans-dominant NFkappaB inhibitors strongly interfere with
IL-6 mRNA
induction both by IL-1beta and by
UTP , which synergistically evoke IL-6 mRNA expression
Yoshida et al., Eur J Pharmacol 2006
:
While a protein kinase C inhibitor ( GF109203X, 10 microM ) was without effect, an intracellular free Ca2+ chelator ( BAPTA-AM, 50 microM ) suppressed
UTP mediated
IL-6 induction
Kobayashi et al., J Pharmacol Sci 2006
(Calcium Signaling) :
UTP causes
interleukin (IL)-6 production via mRNA expression through P2Y(2)/P2Y(4) receptors in human HaCaT keratinocytes ... In the present study, we analyzed the mechanism of
UTP induced
IL-6 production in these cells ... PD98059, a MEK ( mitogen activated protein kinase kinase ) inhibitor, and BAPTA-AM [ O, O'-bis ( 2-aminophenyl ) ethyleneglycol-N, N,N ', N'-tetraacetic acid, tetraacetoxymethyl ester ], an intracellular Ca ( 2+ ) chelator, reduced
UTP induced ERK phosphorylation and
IL-6 mRNA expression ... 2-APB [ ( 2-aminoethoxy ) diphenylborane ], an inositol 1,4,5-trisphosphate ( IP ( 3 ) ) -receptor antagonist, inhibited
UTP induced
IL-6 mRNA expression ; and the action of A23187, a Ca ( 2+ ) ionophore, resembled the action of UTP ... In contrast, protein kinase C ( PKC ) downregulation and pertussis toxin did not affect
UTP induced
IL-6 mRNA expression, suggesting that PKC and G ( i ) are not involved in the UTP induced IL-6 production ... However, AG1478, an epidermal growth factor (EGF)-receptor inhibitor, partially decreased
UTP induced ERK phosphorylation and
IL-6 expression ... These results suggest that
UTP induced
IL-6 production is in part mediated via phosphorylation of ERK through G ( q/11 ) /IP ( 3 ) / [ Ca ( 2+ ) ] ( i ) and transactivation of the EGF receptor
Kobayashi et al., Eur J Pharmacol 2007
:
Cooperation of calcineurin and ERK for
UTP induced
IL-6 production in HaCaT keratinocytes ...
UTP causes
IL-6 production in HaCaT keratinocytes, which is partially inhibited by PD98059, a mitogen activated protein kinase kinase ( MEK ) inhibitor, suggesting that a pathway other than the extracellular signal regulated kinase ( ERK ) pathway is involved in the production ... In the present study, we examined the involvement of calcineurin in the
UTP induced
interleukin (IL)-6 production in HaCaT keratinocytes ... FK506 and cyclosporine A, calcineurin inhibitors, partially inhibited
UTP induced
IL-6 mRNA expression and protein production ... In addition, combined application of FK506 and PD98059 synergistically inhibited the
UTP induced
IL-6 production ... These results suggest that ERK and calcineurin are cooperatively involved in
UTP induced
IL-6 production