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BCL2 — FAS

Text-mined interactions from Literome

Fernandez et al., Dev Dyn 2001 : Bax and Fas , proapoptotic proteins, were detected homogeneously throughout both ventricles in the neonate, while Bcl-2 , an antiapoptotic protein, was not detectable
van der Kolk et al., Leukemia 2002 (Burkitt Lymphoma) : Lastly, Bcl-2 overexpression blocked cyt-c release and the decrease in Deltapsi ( m ), and completely prevented CD95- or BCR mediated apoptosis ; however, it did not affect CD20XL induced cell death
Tung et al., Am J Physiol Heart Circ Physiol 2003 : These changes in the Fas-Fas ligand pathway and Bcl-2 mitochondrial apoptosis regulation are enhanced by complete suppression of antiapoptotic FADD-like IL-1beta converting enzyme inhibitory protein ( FLIP ) ( from 30.5 to 0.0 %, P < 0.01 ) and Bcl-xL ( from 22.5 to 0.1 %, P = 0.03 ) expression among these cells from the earliest days after gene transfer
Almawi et al., J Leukoc Biol 2004 : The antagonism of apoptosis afforded by prosurvival Bcl-2 proteins appeared to be specific for the GCs, as Bcl-2 and Bcl-x ( L ) blocked GC-induced apoptosis in T cell hybridomas but did not affect Fas or activation induced apoptosis
Hua et al., J Immunol 2005 : Effects of Bcl-2 levels on Fas signaling induced caspase-3 activation : molecular genetic tests of computational model predictions
Yuan et al., Mitochondrion 2001 : Using a stable transfected CEM cell line, we show that Bcl-2 suppressed caspase processing in both cytosolic and mitochondrial compartments in response to both staurosporine and Fas ligation
Bilim et al., Br J Cancer 2008 (Carcinoma, Renal Cell...) : Compared to the parental and mock transfected cells, neither clone was more sensitive to conventional chemotherapeutic agents, but both clones were more susceptible to Fas stimulation ( P < 0.0001 ) and to pharmacological Bcl-2 inhibition ( P < 0.0001 ), as well as to a combination of the two ( P < 0.0001 )
Fan et al., Amino Acids 2009 : Taken together, the findings of this study have demonstrated that L-carnitine could induce apoptosis in hepa1c1c7 cells by regulating Fas ligands and inhibiting the expression of Bcl-2
Li et al., Sheng Li Xue Bao 2010 (Atherosclerosis) : As shown in our preliminary study, MCP-1 induced apoptosis of hUVECs in a dose dependent manner at both 24 h and 48 h. FACS and Western blot analysis results in the present study indicated that MCP-1 promoted the expression of proapoptotic proteins Bax and Fas and inhibited the expression of antiapoptotic protein Bcl-2
Mazumdar et al., Cancer Res 2011 (Colonic Neoplasms) : Thus, activated GLI genes repress DR5 and Fas expressions while upregulating Bcl-2 and PDGFRa expressions to inhibit Fas and facilitate cell survival
Wu et al., Environ Toxicol 2013 : Western blot analysis demonstrated that propofol promoted Fas , cytochrome c, caspase-9 and -3 active form and Bax levels, but inhibited Bcl-xl protein level which led to cell apoptosis
Wu et al., Nan Fang Yi Ke Da Xue Xue Bao 2011 (Brain Ischemia...) : To investigate the effect of Bcl-2 overexpression on Fas and TNFR1 mediated apoptosis and its possible mechanism in rat hippocampus following global ischemia/reperfusion ( IR )
Mandal et al., J Biol Chem 1996 : Bcl-2 prevents CD95 ( Fas/APO-1 ) -induced degradation of lamin B and poly ( ADP-ribose ) polymerase and restores the NF-kappaB signaling pathway
Gougeon et al., J Immunol 1997 (Chronic Disease...) : Interestingly, in contrast to the situation found in infected humans, Fas ligation by agonistic Abs or recombinant human Fas ligand on CD4 and CD8 T cells from infected chimpanzees did not induce apoptosis in these subsets even when Bcl-2 was down-regulated
Brás et al., J Immunol 1997 (Lymphoma, B-Cell) : In this system, Fas ligation also triggers Bcl-2/Bcl-x down-regulation, an effect inhibited by sIgG cross linking, the cysteine protease inhibitor acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone, and PMA treatment ... In A20 cells, Fas signaling may thus trigger both ICE activation and Bcl-x and Bcl-2 down-regulation
Srinivasan et al., J Biol Chem 1998 (Breast Neoplasms) : Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells ... In some cells, Bcl-xL overexpression can inhibit anti-Fas- and tumor necrosis factor (TNF)-alpha induced apoptosis
Wakisaka et al., Clin Exp Immunol 1998 (Arthritis, Rheumatoid) : Anti-Fas MoAb induced apoptosis of RA synovial cells in vitro, and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-1beta, but not IL-6 or IL-8, inhibited the anti-Fas induced apoptosis accompanying up-regulation of Bcl-2 protein expression and reduced expression of CPP32 and ICH-1L. Immunohistochemical study revealed that CPP32 and ICH-1L were expressed weakly in the RA synovial lining cells compared with osteoarthritis ( OA ) synovial lining cells
Fulda et al., Cancer Res 1998 (Neuroblastoma) : After Doxo treatment, enhanced CD95/CD95-L expression and caspase-8 activation were not blocked by Bcl-2 or Bcl-X ( L ) and were found in cells with a mitochondrial transmembrane potential ( delta psi ( m ) ) that was still normal ( delta psi ( m ) high cells )