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APOB — KLF2

Text-mined interactions from Literome

Li et al., Cell Physiol Biochem 2011 : Furthermore, ox-LDL increased pro-inflammatory adhesion molecules but inhibited KLF2 expression was reversed by addition of Tregs
Kumar et al., Arterioscler Thromb Vasc Biol 2013 (Atherosclerosis...) : The purpose of this study is to determine whether and how LDL affects endothelial KLF2 expression ... LDL induced decrease in KLF2 parallels changes in endothelial KLF2 target genes thrombomodulin, endothelial NO synthase, and plasminogen activator inhibitor-1 ... Knockdown of myocyte enhancing factor-2, or mutation of the myocyte enhancing factor-2 site in the KLF2 promoter, abrogates LDL induced downregulation of endothelial KLF2 and thrombomodulin, and KLF2 promoter activity ... Similarly, knockdown of enhancer of zeste homolog 2 negates LDL induced downregulation of KLF2 and thrombomodulin in endothelial cells ... LDL represses endothelial KLF2 expression via DNA and histone methylation