Gene interactions and pathways from curated databases and text-mining

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EPHB2 — PTPN5

Text-mined interactions from Literome

Paul et al., Nat Neurosci 2003 (MAP Kinase Signaling System) : We have investigated the role of STEP , a striatal enriched tyrosine phosphatase, in the regulation of ERK activity in rat neurons
Paul et al., Biol Psychiatry 2007 (Translocation, Genetic) : Inhibitors of ERK1/2 activation or of protein translation block the synthesis of STEP within the LA after fear conditioning
Kim et al., Exp Neurol 2008 : Here, we investigate the role of STEP in D2R mediated ERK signaling, especially in dopaminergic neuronal development
Venkitaramani et al., Synapse 2009 : These data demonstrate more conclusively the role of STEP in the regulation of ERK1/2 activity
Pulido et al., EMBO J 1998 : PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal regulated kinases ERK1 and ERK2 by association through a kinase interaction motif