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AHSA1 — FAS
Text-mined interactions from Literome
Ivanov et al., Oncogene 2000
(Melanoma) :
Inhibition of
p38 activity also
restored NF-kappaB activity and
Fas expression in early-phase melanoma cells, suggesting that p38 elicited suppression of Fas expression is not restricted to late phase melanoma
Choi et al., J Neurooncol 2002
(Astrocytoma...) :
Herein, we demonstrate that : ( 1 ) Among these cytokines, only IL-6 was induced upon Fas ligation in a dose- and time dependent manner ; ( 2 ) A selective
p38 MAP kinase inhibitor, SB202190, and a MEK inhibitor, U0126,
suppressed induction of IL-6 mRNA and protein expression by
Fas ligation ; and ( 3 ) Glioblastoma multiforme samples ( n = 11 ) contain significantly higher levels of IL-6 compared to those of control brains ( n = 5 ), which correlate with increased levels of Fas
Juo et al., Mol Cell Biol 1997
:
In this study, crmA antagonized, and YVAD-CMK and Z-VAD-FMK completely inhibited,
Fas activation of
p38 kinase activity, demonstrating that Fas dependent activation of p38 requires ICE/CED-3 family members and conversely that the MKK3/p38 activation cascade represents a downstream target for the ICE/CED-3 family proteases