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APP — SORL1

Text-mined interactions from Literome

Spoelgen et al., J Neurosci 2006 : Thus, sorLA interacts both with BACE and APP and might therefore directly affect BACE-APP complex formation ... We discovered that sorLA significantly reduced BACE-APP interactions in Golgi
Rogaeva et al., Nat Genet 2007 (Alzheimer Disease) : These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease
Ma et al., Arch Neurol 2009 (Alzheimer Disease...) : T o detect soluble LR11 and APP in cerebrospinal fluid (CSF) from patients with AD and control subjects, as ( like beta-amyloid precursor protein ) LR11 is cleaved near the membrane to release a large N-terminal fragment that is secreted to media from cultured cells
Schmidt et al., EMBO J 2012 (Alzheimer Disease) : We also show that SORLA prevents APP oligomerization both in cultured cells and in the brain in vivo, eliminating the preferred form of the substrate and causing secretases to switch to a less efficient non-allosteric mode of action
Herskowitz et al., Mol Biol Cell 2012 (Alzheimer Disease) : We report that the LR11 ectodomain is required for LR11 mediated reduction of Aß and that mutagenesis of the LR11 Golgi localizing, ?-adaptin ear homology domain, ADP-ribosylation factor ( GGA ) -binding motif affects the endosomal distribution of LR11 , as well as LR11 's effects on APP traffic and Aß production