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IGF1 — STAT5B

Text-mined interactions from Literome

Sawka-Verhelle et al., Endocrinology 2000 (Carcinoma, Hepatocellular...) : Firstly, we show that both insulin and insulin-like growth factor I lead to tyrosine phosphorylation of Stat 5B , and this promotes binding of the transcription factor to the beta-casein promoter containing a Stat 5 binding site
Davey et al., Endocrinology 2001 : STAT5b is required for GH-induced liver IGF-I gene expression ... Here, we evaluate the role of STAT5b in GH activation of Igf-I by monitoring the induction of Igf-I mRNA in livers of wild-type and Stat5b ( -/- ) mice stimulated with exogenous pulses of GH ... Thus, STAT5b plays an important and specific role in liver Igf-I gene expression
Woelfle et al., J Biol Chem 2003 : To test the role of Stat5b in GH-stimulated IGF-I gene expression, we have delivered modified versions of the protein to pituitary-deficient male rats by quantitative adenovirus mediated gene transfer ... Dominant negative Stat5b completely prevented GH-stimulated IGF-I gene transcription, whereas constitutively active Stat5b led to robust IGF-I gene expression in the absence of hormone
Hwa et al., J Biol Chem 2004 : In summary, our results provide evidence of the following in human primary dermal fibroblasts : ( a ). IFN-gamma preferentially activates STAT-5b, but, in the absence of a functional STAT-5b, STAT-5a is activated ; ( b ). IFN-gamma time-dependently up-regulates IGF-I mRNA expression ; ( c ). the regulation of IGF-I requires an active STAT-5b , and activated STAT-5a can not substitute for an inactive STAT-5b ; and ( d ). STAT-5b has an essential role in the transcriptional up-regulation of IGF-I
Woelfle et al., Am J Physiol Endocrinol Metab 2004 : Constitutive-active STAT5b stimulated robust transcription of IGF-I , ALS, and IGFBP-3 in the absence of hormone but did little to modify GH-mediated activation of SOCS family genes
Rosenfeld et al., J Pediatr Endocrinol 2004 : Growth in H. sapiens depends largely on GH-dependent STAT5b regulation of IGF-I expression
Hwa et al., J Clin Endocrinol Metab 2005 (Growth Disorders) : The identification of a second case of severe growth failure associated with STAT5b mutation implicates a unique and critical role for STAT5b in GH stimulation of IGF-I gene expression and statural growth
Woelfle et al., Exp Clin Endocrinol Diabetes 2007 (Body Weight...) : Recent work revealed a critical role for the transcription factor STAT5b in GH stimulated IGF-I gene expression
Rosenfeld et al., Trends Endocrinol Metab 2007 (Growth Disorders) : These patients define a new cause of GH insensitivity and primary IGF deficiency and confirm the crucial role of STAT5b in GH-mediated IGF-I gene transcription
Chia et al., J Biol Chem 2010 : These sites could bind Stat5b in vitro, and individual domains could mediate GH- and Stat5b stimulated IGF-I promoter activity in cultured cells
Wu et al., J Biol Chem 2011 : It has been shown that the transcription factor Stat5b mediates the GH promoting effect on IGF-1 expression and on chondrogenesis, yet it is not known whether other signaling molecules are activated by GH in growth plate chondrocytes