Ohba et al., Hokkaido Igaku Zasshi 2001
:
In 293T cells, Rap2 was regulated by the same set of guanine nucleotide exchange factors ( GEFs ) and GTPase activating proteins ( GAPs ) as those which regulated Rap1 Huston et al., Proc Natl Acad Sci U S A 2008
:
Intersecting regulatory inputs for cAMP employ EPAC to transduce positive effects, namely the Rap2 dependent nuclear exit and activation of DNA-PK , whereas protein kinase A (PKA) provides the negative input by antagonizing these actions
Vuchak et al., Cell Adh Migr 2011
(Colonic Neoplasms) :
Overexpression of Rap1GAP in human colon cancer cells impaired Rap2 activity and the ability of cells to spread and migrate on collagen IV