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CPZ — IL10

Text-mined interactions from Literome

Tarazona et al., J Immunol 1995 (Shock, Septic) : Whereas only low, if any, serum IL-10 levels are detectable by ELISA after injection of CPZ, bacterial LPS, or staphylococcal enterotoxin B (SEB) alone, simultaneous administration of CPZ + LPS or CPZ + SEB causes a significant increase in IL-10 production in vivo ... The blockade of dopamine type 1 ( D1 ) but not type 2 ( D2 ) receptors abolishes the CPZ effect on IL-10 production
Mengozzi et al., Immunology 1994 : Therefore, CPZ is a more specific inhibitor of TNF production than DEX ; in particular, CPZ increased the induction of IL-10 , which is a ` protective ' cytokine known to inhibit LPS toxicity and TNF production
Ikeda et al., Immunol Lett 1997 : CPZ down-regulated tumor necrosis factor-alpha (TNF-alpha) and up-regulated IL-10 in mice that then received ConA, whereas delayed administration of CPZ had no effect