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IFI27 — RB1

Text-mined interactions from Literome

Alexander et al., Mol Cell Biol 2001 : In addition, the use of pRb proteins mutated in the pocket domain demonstrates that pRb upregulation of p27 ( KIP1 ) and senescence induction do not require the interaction of pRb with E2F
Leshem et al., J Cell Physiol 2002 : Phosphorylation of pRb is required for HGF induced muscle cell proliferation and is p27kip1 dependent
Coulonval et al., Exp Cell Res 2003 : In the presence of TSH, transforming growth factor beta ( TGFbeta ) did not affect the assembly of cyclin D3-CDK4, but it strongly inhibited the pRb-kinase activity associated with both cyclin D3 and p27, not only by preventing the nuclear import of cyclin D3-CDK4 and its binding to p27 , but also by inhibiting CDK4 phosphorylation within residual p27 bound cyclin D3-CDK4 complexes
Jia et al., J Cell Mol Med 2009 : Overexpression of phosphatase and tensin homologue deleted on chromosome 10 ( PTEN ) in SV SMCs followed by IGF-1 activation significantly decreased the expression of cyclin E and pRb and induced p27 expression in SV SMCs, while, pRb levels were markedly decreased and p27 levels were significantly increased in IMA SMCs. Silencing the PTEN gene by siRNA transfection of IMA SMCs significantly induced the expression of pRb and inhibited p27 expression, while, the expression levels of cyclin E, pRb, p21 and p27 were unaffected by the silencing of PTEN in SV SMCs
Vlach et al., EMBO J 1996 : p27 expressed from recombinant retroviruses in Rat1 cells associated with and inhibited cyclin E/CDK2 complexes, induced accumulation of the pRb and p130 proteins in their hypophosphorylated forms, and arrested cells in G1