Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
STAT5B
→
IL2RB
(directlyIncreases, IL2RB Activity, STAT5B Activity)
Lin et al., Oncogene 2000* Evidence: Stat5 proteins activated by IL-2. The phosphorylated tyrosines on IL-2Rbeta can then serve as docking sites for signaling molecules that otherwise cannot associate with IL-2Rbeta, including the adaptor protein Shc, Stat5a, and Stat5b (Figure 2). For example, only phosphorylated (but not non-phosphorylated) peptides spanning either Tyr-392 or Tyr-510 of IL-2Rbeta can efficiently compete with IL-2-induced Stat5 DNA binding to a GAS motif
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
Nmi/STAT5 complex (NMI-STAT5A_STAT5B)
(modification, activates)