◀ Back to CDK2
AKT2 — CDK2
Text-mined interactions from Literome
Maddika et al., J Cell Sci 2008
:
Akt mediated phosphorylation of
CDK2 regulates its dual role in cell cycle progression and apoptosis ... Here, we show that
CDK2 , an S-phase cyclin dependent kinase, is a novel
target for
Akt during cell cycle progression and apoptosis ... Although
CDK2 threonine 39 phosphorylation
mediated by
Akt enhances cyclin-A binding, it is dispensable for its basal binding and the kinase activity
Yin et al., Prostate 2009
(Prostatic Neoplasms) :
In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with
CDK2 , CDK4, and E2F and by
activation of
AKT
Villavicencio et al., Gynecol Oncol 2009
(Endometrial Hyperplasia...) :
The PCOS condition is associated with increased
Ser473-AKT phosphorylation, elevated expression of Ras, increased cytoplasmic abundance of p27, and
increased nuclear abundance of
CDK2 in the endometrial epithelial cells