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CCK — PLD3
Text-mined interactions from Literome
Murthy et al., Am J Physiol Gastrointest Liver Physiol 2001
:
The identity of G proteins mediating
CCK stimulated
phospholipase D ( PLD ) activity was determined in intestinal smooth muscle cells ...
CCK stimulated
PLD activity was partly mediated by RhoA and could be inhibited to the same extent ( 47 +/- 2 % to 53 +/- 6 % ) by 1 ) a dominant negative RhoA mutant, 2 ) RhoA antibody or Galpha(13) antibody, and 3 ) Clostridium botulinum C3 exoenzyme
Rivard et al., Am J Physiol 1995
:
This study was performed to determine by which effector systems
CCK regulates tyrosine kinases, phosphatidylinositol ( PtdIns ) 3-kinase, and
phospholipase D ( PLD ) activities
Rydzewska et al., Digestion 1995
:
Specificity of
phospholipase D activation by
cholecystokinin and phorbol myristate acetate but not by carbamylcholine and A23187 in rat pancreatic acini
Bosch et al., Biochem J 1999
:
CCK8 induced
PLD activation was inhibited by 90 % in the absence of external Ca2+, demonstrating that receptor mediated activation of PKC in itself does not significantly add to PLD activation but requires a sustained increase in [Ca2+ ] i. Taken together, the results presented demonstrate that, in CHO-CCK-A cells, receptor mediated PLD activation is completely dependent on PKC, but that the extent to which PLD becomes activated depends largely, if not entirely, on the magnitude and duration of the agonist induced increase in [ Ca2+ ] i