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RPS27L — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., Cancer Res 2007
(Genomic Instability) :
Through this mechanism,
RPS27L induction by
p53 facilitates p21 mediated cell cycle arrest and protects against DNA damage induced apoptosis
Xiong et al., Oncogene 2011
:
Ectopic expression of
RPS27L or RPS27 inhibits MDM-2 mediated p53 ubiquitination and
increases p53 levels by extending p53 protein half-life, whereas siRNA silencing of RPS27L decreases p53 levels by shortening p53 half-life, with a corresponding reduction in p53 transcription activity