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BAX — PARP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kawano et al., Anticancer Res 2004
(MAP Kinase Signaling System) :
The combination treatment activated caspase-3 and cleaved
PARP , but it did not
induce any notable change in the expression of Bcl-XL, Bcl-2 and
Bax compared with each single treatment
Eom et al., Biol Pharm Bull 2008
(Brain Neoplasms...) :
Berberine treatment also markedly enhanced apoptosis in T98G cells through the induction of a higher ratio of the
Bax/Bcl-2 proteins, the disruption of mitochondrial membrane potential, and the
activation of procaspase-9, caspase-9, caspase-3, and poly ( ADP-ribose ) polymerase (
PARP )
Jeon et al., Exp Mol Med 2008
(Seizures) :
Protein levels of Bcl-2, Bcl-X ( L ),
Bax , and Bad showed no change, and cleavage of caspase-3 and
PARP were not
induced
Lee et al., Oncol Rep 2010
(Adenocarcinoma...) :
In this study, we examined the chemoresistance to 5-Fluorouracil ( 5-FU ) using MCF-7 breast cancer MTS. 5-FU ( 400 microM ) induced apoptosis in MCF-7 cell monolayer as determined by HO/PI staining,
PARP cleavage, p53 induction,
Bax induction , and Bcl-2 down-regulation
Bhattarai et al., Biol Pharm Bull 2012
(Carcinoma, Squamous Cell...) :
Fomitoside-K could induce a dose and time dependent apoptosis in YD-10B cells as characterized by cell morphology, cell cycle arrest, inhibition of survivin,
activation of poly ( ADP-ribose ) polymerase (
PARP ), caspase-3, -9 and an increased expression ratio of
Bax/Bcl-2
Li et al., J Biosci 2012
(Carcinoma, Squamous Cell...) :
Further results showed that swainsonine treatment up-regulated
Bax , downregulated Bcl-2 expression, triggered Bax translocation to mitochondria, destructed mitochondria integrity and activated mitochondria mediated apoptotic pathway, followed by the release of cytochrome c, which in turn activated caspase-9 and caspase-3,
promoted the cleavage of
PARP , resulting in Eca-109 cell apoptosis
Mou et al., Int J Biochem Cell Biol 2013
(Neoplasms) :
Further studies with HCT8 cells showed that knockdown of FAM3B increased the protein levels of membrane bound Fas and
Bax , reduced the expression of Bcl-2,
promoted the cleavage of caspases-8, -3, -9 and PARP, and the nuclear translocation of cleaved
PARP
Piedfer et al., Biochim Biophys Acta 2013
(Leukemia, Myeloid, Acute) :
The flavone 's apoptotic action in U937 cells was associated with recruitment of mitochondria,
Bax activation , Bad dephosphorylation ( at Ser ( 136 ) ), activation of caspases -8, -9, and -3 and cleavage of the caspase substrate
PARP-1