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CD4 — IL18

Text-mined interactions from Literome

Greene et al., J Immunol 2000 (Sarcoidosis, Pulmonary) : Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis
Choi et al., J Infect Dis 2001 (HIV Infections) : IL-18 also reduced cell surface expression of the HIV-1 receptor CD4
Karni et al., J Neuroimmunol 2002 (Multiple Sclerosis) : IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4 ( + ) T cells via CD40-CD40 ligand interactions
Nakano et al., Int Immunol 2003 : Furthermore, IL-18R-, CD4- or stat6-deficient mice transplanted with the lesions did not produce IgE, indicating that this IgE response is initiated by IL-18 , and dependent on host derived CD4 ( + ) T cells and stat6
Noble et al., Immunology 2003 : CD4 and CD8 T cells induced IL-18 from DC and primed for IL-12 p70 secretion via interferon-gamma (IFN-gamma) or tumour necrosis factor-alpha (TNF-alpha)
Fukaura et al., Nihon rinsho. Japanese journal of clinical medicine 2003 (Encephalomyelitis, Autoimmune, Experimental...) : IL-18 is linked to raised IFN-gamma in MS and is induced by activated CD4 ( + ) T cells via CD40-CD40 ligand interaction
Li et al., Cancer Res 2005 (Fibrosarcoma) : IL-12 and IL-18 stimulated CD4 ( + ) TDLN cells and enhanced IFNgamma production by CD4 ( + ) cells to a greater extent than by CD8 ( + ) cells
Pepe et al., Curr Pharm Des 2006 : This Th1 polarizing activity is mediated by interleukin-12 released by infected CDs in the presence of CD4 ( + ) cells
Cao et al., Hum Immunol 2007 (Carcinoma, Hepatocellular...) : alpha-fetoprotein and interleukin-18 gene modified dendritic cells effectively stimulate specific type-1 CD4- and CD8 mediated T-Cell response from hepatocellular carcinoma patients in Vitro
Ariga et al., Immunology 2007 : Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive CD4 ( + ) T cells induces transient T-bet expression, interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Bagchi et al., J Clin Immunol 2010 (Dysentery, Bacillary) : It is assumed that the role of caspase-1 in inducing the CD4+ T cell activity increased with IL-18 rather than CD8+ suppressor cell activity
Vandergeeten et al., Blood 2013 (HIV Infections) : When administered to HIV infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4 ( + ) T cells by promoting their survival and proliferation
Suzuki et al., J Virol 1999 : Among them, interleukin-12 (IL-12) and IL-4 induce naive CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively