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BDNF — GAP43
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Encinas et al., J Neurochem 1999
(Neuroblastoma) :
The mitogen activated protein kinase and ERK kinase ( MEK ) inhibitor PD98059 blocks
BDNF induced neurite outgrowth and
growth associated protein-43 expression but has no effects on cell survival
Young et al., J Neurosci Methods 1999
:
The
effects of nerve growth factor (NGF), neurotrophin-3 (NT-3) and
brain derived neurotrophic factor (BDNF) on
GAP-43 immunoreactivity in dissociated primary cultures of rat and chick dorsal root ganglia have been compared to results obtained by cell counting
Klöcker et al., Neurobiol Dis 2001
:
Here, we characterized the
effects of the survival promoting neurotrophin
brain derived neurotrophic factor (BDNF) on mRNA expression of
GAP-43 , L1, TAG-1, and SC-1 in axotomized and regenerating rat retinal ganglion cells ( RGCs ) ... This led us to hypothesize that the
BDNF effects on
GAP-43 , L1, and TAG-1 mRNA expression are mediated by a NO-dependent mechanism
Leaver et al., Gene Ther 2006
(Optic Nerve Injuries) :
At 7 weeks after ON crush, quantification of betaIII-tubulin immunostaining revealed that, compared to AAV-GFP controls, RGC survival was not enhanced by
AAV-GAP43-GFP but was
increased in AAV-CNTF-GFP ( mean RGCs/retina : 17 450+/-358 s.e.m. ) and
AAV-BDNF-GFP injected eyes ( 10 200+/-4064 RGCs/retina )
Wang et al., Nan Fang Yi Ke Da Xue Xue Bao 2010
:
[
Effect of endogenous
brain derived neurotrophic factor on
GAP-43 expression in the anterior horn of the spinal cord in rats with sciatic nerve injury ] ... To investigate the
effect of endogenous
brain derived neurotrophic factor (BDNF) on
GAP-43 expression in the anterior horn of the spinal cord in rats following sciatic nerve injury ... Endogenous
BDNF may
regulate the expression of
GAP-43 in the spinal cord anterior horn after sciatic nerve injury in rats
Fournier et al., J Neurosci Res 1997
(Optic Nerve Injuries) :
We conclude that
BDNF specifically
enhances GAP-43 but not T alpha1 mRNA levels in injured RGCs