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OTX2 — WNT1

Pathways - manually collected, often from reviews:

• WikiPathways Dopaminergic Neurogenesis: OTX2 → WNT1 (activation)

Text-mined interactions from Literome

Westenskow et al., Development 2009 : We conclude that Wnt/beta-catenin signaling is required for differentiation of the RPE by directly regulating the expression of Mitf and Otx2
Rössler et al., Neuroscience 2010 : We found that Shh, FGF8 and Wnt1 induced the expression of Lmx1a and Otx2 in nmNSCs resulting in the differentiation of up to 39 % of the nmNSCs into neurons expressing Pitx3