◀ Back to SMURF1
SMURF1 — SMURF2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2)
→
TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
Reactome Reaction:
SMURF2
→
SMURF1
(reaction)
Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Kuratomi et al., Biochem J 2005
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., Proc Natl Acad Sci U S A 2001
:
These findings suggest that
Smurf2 may
regulate the competence of a cell to respond to transforming growth factor-beta/bone morphogenetic protein signaling through a distinct degradation pathway that is similar to, yet independent of,
Smurf1
Fukunaga et al., J Biol Chem 2008
(Bone Neoplasms...) :
Smurf2 induces ubiquitin dependent degradation of
Smurf1 to prevent migration of breast cancer cells ... In the present study, we show the post-translational
regulation of
Smurf1 by
Smurf2 and the functional differences between Smurf1 and Smurf2 in the progression of breast cancer cells
Lee et al., Nature communications 2011
:
Smurf1 interaction with MyD88 appears to be
mediated by Smad6, and
Smurf2 interaction by Smurf1