◀ Back to ARF6

ARF6 — HMGA2

Text-mined interactions from Literome

Tzatsos et al., Cell stem cell 2008 : Ink4a/Arf regulation by let-7b and Hmga2 : a genetic pathway governing stem cell aging
Markowski et al., Genes Chromosomes Cancer 2011 (Neoplasms) : To see if p14(Arf) can repress HMGA2 by a TP53 dependent mechanism, nutlin-3, a known MDM2 antagonist, was used which not only increased the activity of the senescence, associated markers p21 and beta-galactosidase, but also decreased the expression of HMGA2, suggesting that p14(Arf) indeed influences HMGA2 by a p53 dependent mechanism because nutlin-3 stabilizes p53 ... As to the interaction between HMGA2 and p14(Arf) in benign tumorigenesis, we propose a model where akin to MSC self-renewal during tissue repair the simultaneous increase of p14(Arf) with HMGA2 ensures genomic stability, whereas in turn p14(Arf) can repress HMGA2 via TP53