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GSTA2 — NPY

Text-mined interactions from Literome

Breton et al., Gen Comp Endocrinol 1991 : In both cases NPY alone induced a twofold increase in GtH2 secretion and peaked 2 to 4 hr administration regardless of the route of injection
Peng et al., Gen Comp Endocrinol 1993 : Together, these results suggest that NPY may play a physiological role in the regulation of GH and GtH-II secretion in the goldfish
Peng et al., Endocrinology 1993 : Both synthetic human NPY and NPY- ( 18-36 ), an agonist selective for the NPY Y2-receptor, stimulated GH and GtH-II release from the pituitary fragments ; the magnitude of the response to NPY ( 18-36 ) was smaller than that to the whole molecule of NPY ... NPY also stimulated the release of GH and GtH-II from perifused dispersed pituitary cells ... In contrast, NPY- ( 18-36 ) had no effect on either GH or GtH-II release from dispersed pituitary cells ... Furthermore, a GnRH antagonist significantly reduced the effects of NPY on both GH and GtH-II release in perifused pituitary fragments ... One site of action is the pituitary cells, where NPY directly stimulates GH and GtH-II secretion ; the second is the nerve terminals, where NPY presynaptically stimulates GnRH release via Y2-like receptors, and GnRH, in turn, stimulates GH and GtH-II release