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MAPK3 — REG1A
Text-mined interactions from Literome
Zúñiga et al., J Biol Chem 1999
:
Our results demonstrate that the noncatalytic region of PTP-SL associates with mitogen activated protein kinases with high affinity and specificity, providing a mechanism for substrate specificity, and suggest a
role for
PTP-SL in the regulation of
mitogen activated protein kinase translocation to the nucleus upon activation
Patel et al., Front Neuroendocrinol 1999
:
The five receptors share common signaling pathways such as the inhibition of adenylyl cyclase,
activation of
phosphotyrosine phosphatase (PTP) , and modulation of
mitogen activated protein kinase ( MAPK ) through G-protein dependent mechanisms ... Four of the receptors ( SSTR1, 2, 4, and 5 ) induce cell cycle arrest via
PTP dependent modulation of
MAPK , associated with induction of the retinoblastoma tumor suppressor protein and p21
Wu et al., J Clin Endocrinol Metab 1997
:
Consistent with the interpretation that the effect of fluoride on the steady state tyrosyl phosphorylation level of
p44mapk is a
consequence of an inhibition of a
phosphotyrosyl phosphatase (PTP) , mitogenic doses of orthovanadate, a bone cell mitogen and a PTP inhibitor, also increased the steady state tyrosyl phosphorylation level of p44mapk, but not p42mapk, in a time dependent sustained manner similar to that observed with fluoride ... Together, these findings support the concept that inhibition of a
PTP activity in bone cells could
lead to an activation of
MAPK activity