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CSNK1A1L — TP53

Text-mined interactions from Literome

Huart et al., J Biol Chem 2009 : CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability ... Depletion of CK1 using small interfering RNA or inhibition of CK1 using the kinase inhibitor ( D4476 ) activated p53 and destabilized E2F-1, indicating that steady-state levels of these proteins are controlled by CK1
Huart et al., PloS one 2012 : Pharmacological inhibition of CK1 increases p53 protein level and induces cell death, whilst small interfering RNA mediated depletion of CK1a stabilizes p53 and induces growth arrest