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HIF1A — HIPK2

Text-mined interactions from Literome

Nardinocchi et al., Biochim Biophys Acta 2009 (Neoplasms...) : Starting from the finding that HIPK2 knockdown by RNA-interference ( HIPK2i ) induced significant up-regulation of HIF-1alpha mRNA and of its target VEGF in tumor cells, we evaluated the role of HIPK2 in transcriptional regulation of HIF-1alpha ... These findings provide the first evidence of HIPK2 mediated transcriptional regulation of HIF-1alpha that might play a critical role in VEGF expression
Nardinocchi et al., Molecular cancer 2009 : Here, we investigated whether the HIPK2 overexpression could downregulate HIF-1alpha expression and activity in tumor cells treated with hypoxia mimicking condition, and evaluated whether HIPK2 dependent downregulation of HIF-1alpha could sensitize chemoresistant tumor cells to adriamycin ( ADR ) -induced apoptosis