◀ Back to MMP9
MMP9 — SLC22A3
Text-mined interactions from Literome
Stallings-Mann et al., Cells Tissues Organs 2007
(Cell Transformation, Neoplastic) :
We have identified the induction of Rac1b, an alternatively spliced variant of Rac1, as a key event in
MMP induced
EMT
Lee et al., Carcinogenesis 2008
(Breast Neoplasms...) :
Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances
EMT induced by TGF-beta in mammary epithelial cells via a
MMP dependent mechanism
Tan et al., Am J Pathol 2010
(Fibrosis...) :
AMCM induced tubular cell
EMT in C1.1 cells was
inhibited by broad-spectrum
MMP inhibitor ( GM6001 ), MMP-2/9 inhibitor, and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 ... AMCM induced
EMT in primary tubular epithelial cells was
inhibited by
MMP-2/9 inhibitor ...
MMP-9 induced tubular cell
EMT in both C1.1 cells and primary tubular epithelial cells ... Furthermore,
MMP-9 induced tubular cell
EMT in C1.1 cells to an extent similar to transforming growth factor-beta
Asuthkar et al., Neuro Oncol 2011
(Cerebellar Neoplasms...) :
Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses
MMP-9 mediated
EMT ... Alternatively, inhibition of
MMP-9 ( pM )
resulted in upregulation of Gadd45a and suppression of
EMT
Tan et al., Lab Invest 2013
(Fibrosis...) :
Early- and late-stage inhibition of
MMP-9 in UUO mice significantly
reduced tubular cell
EMT and renal fibrosis ... A pro-fibrotic
role of
matrix metalloproteinase-9 (MMP-9) in tubular cell
epithelial-mesenchymal transition (EMT) is well established in renal fibrosis ; however studies from our group and others have demonstrated some previously unrecognized complexity of MMP-9 that has been overlooked in renal fibrosis ... In summary, our result suggests that
MMP-9 of both TEC and macrophage origin may directly or indirectly contribute to the pathogenesis of renal fibrosis via osteopontin cleavage, which, in turn further recruit macrophage and
induce tubular cell
EMT