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CFTR — IL8

Text-mined interactions from Literome

Schwiebert et al., Am J Physiol 1999 (Cystic Fibrosis...) : Together, these results suggest that 1 ) RANTES expression is altered in CF epithelia and 2 ) epithelial expression of RANTES, but not IL-8 or MCP-1, is dependent on CFTR
Perez et al., Am J Physiol Lung Cell Mol Physiol 2007 (Cystic Fibrosis...) : CFTR ( inh ) -172 does not affect IL-8 , IL-6, or granulocyte/macrophage colony stimulating factor secretion in two CF phenotype immortalized cell lines : 9/HTEo ( - ) pCEP-R and 16HBE14o ( - ) AS, or IL-8 secretion in primary CF cells, and inhibitor withdrawal abolishes the increased response, so CFTR ( inh ) -172 effects on cytokines are not direct
Xu et al., PloS one 2010 : Reduction of CFTR expression in AM resulted in increased secretion of IL-8 , increased phosphorylation of NF-kappaB, a positive regulator of IL-8 expression, and decreased expression of IkappaB-alpha, the inhibitory protein of NF-kappaB activation
Black et al., Am J Respir Cell Mol Biol 1998 (Cystic Fibrosis) : We conclude that the absence of functioning CFTR alone is not sufficient to cause excessive production of IL-8