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CEACAM1 — NFKB1
Text-mined interactions from Literome
Muenzner et al., J Biol Chem 2001
:
Gonococcal infection activated a
nuclear factor-kappaB (NF-kappaB) heterodimer consisting of p50 and p65, and inhibitors that prevent the nuclear translocation of activated NF-kappaB complex
inhibited CEACAM1 transcript expression ... The
regulation of
CEACAM1 expression by
NF-kappaB also implies a broader role for this receptor in the general inflammatory response to infection
Muenzner et al., J Biol Chem 2002
:
N. gonorrhoeae triggered
CEACAM1 up-regulation
involves activation of the transcription factor nuclear factor kappaB
(NF-kappaB) , which translocates as a p50/p65 heterodimer into the nucleus, and an NF-kappaB-specific inhibitory peptide inhibited CEACAM1-receptor up-regulation in N. gonorrhoeae infected HOSE cells
Slevogt et al., Nat Immunol 2008
:
Here we demonstrate that the interaction of
CEACAM1 with ubiquitous surface protein A1 expressed on M. catarrhalis or with opacity associated proteins on N. meningitidis resulted in reduced Toll-like receptor 2-initiated transcription factor
NF-kappaB dependent inflammatory responses of primary pulmonary epithelial cells