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HSPD1 — NFKB1

Text-mined interactions from Literome

Kol et al., J Clin Invest 1999 : We also tested whether either HSP 60 induces nuclear factor-kappaB (NF-kappaB) , which contributes to the gene expression of these molecules ... In ECs, either HSP 60 triggered activation of NF-kappaB complexes containing p65 and p50 Rel proteins
Billack et al., Am J Physiol Cell Physiol 2002 : Mobility shift assays revealed that HSP60 induced NF-kappaB and CRE binding activity, while CCAAT/enhancer binding protein (C/EBP), which binds to NF-IL-6, was constitutively active in the cells
Gobert et al., J Biol Chem 2004 : H. pylori HSP60 induced IL-6 mRNA expression, and NF-kappaB activation in RAW 264.7 cells was abrogated in the presence of MG-132, a proteasome inhibitor
Kim et al., Bone 2009 (Bone Resorption) : In addition, HSP60 activated p38 and NFkappaB , but not ERK or JNK ; importantly, inhibitors of p38 ( SB203580 ) and NFkappaB ( PDTC ) abolished HSP60 induced apoptosis ... Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis, caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK
Wang et al., J Mol Cell Cardiol 2010 (Heart Failure) : TNFalpha treatment was used to test the role of NFkappaB activation in HSP60 expression in a cardiac cell line
Cappello et al., PloS one 2011 (Pulmonary Disease, Chronic Obstructive) : Hsp60 induction by NFkB-p65 and its release by epithelial cells after oxidative stress can have a role in maintaining inflammation, e.g., by stimulating neutrophils activity