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NFKB1 — NLRP3

Text-mined interactions from Literome

Dowds et al., Biochem Biophys Res Commun 2003 (Familial Mediterranean Fever) : Notably, pyrin, the product of the familial Mediterranean fever gene, inhibited cryopyrin mediated apoptosis and NF-kappaB activation by disrupting the cryopyrin-ASC interaction
O'Connor et al., J Immunol 2003 : Transfection of full-length CIAS1 or either of two shorter, naturally occurring isoforms dramatically inhibited TNF-alpha induced activation of NF-kappaB reporter activity
Hoffman et al., Lancet 2004 (Acute Disease...) : Involvement of cryopyrin in activation of caspase 1 and NF-kappaB signalling suggests that it might have a role in many chronic inflammatory diseases
Yu et al., Cell Death Differ 2006 (Inflammation) : Using a HEK293 cell based reconstitution system that stably expresses ASC and procaspase-1 we demonstrated that neither cryopyrin nor pyrin or their corresponding disease associated mutants could significantly activate NF-kappaB in this system
Saito et al., Arthritis Rheum 2005 (Chronic Disease...) : In addition, the Y570C mutation ( with or without the S196N polymorphism ) increased the ability of CIAS1 to induce ASC dependent NF-kappaB activation, unlike the wild-type gene or the gene bearing the S196N polymorphism alone
Fontalba et al., J Immunol 2007 : Thus, NLRP2 may control NF-kappaB activation through a regulatory loop