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FOXO1 — IRS2
Text-mined interactions from Literome
Guo et al., Mol Endocrinol 2006
:
By contrast, insulin stimulation of Irs1 ( -/- ) MEFs caused
FoxO degradation, not only because
Irs2 expression
increased but also because Irs2 efficiently activated p110alpha -- > Akt cascade ... Inhibition of
Irs2 degradation with rapamycin
caused persistent
FoxO degradation even during prolonged insulin stimulation
Shimano et al., J Mol Med (Berl) 2007
(Insulin Resistance...) :
Taken together,
TFE3/Foxo1 and SREBP-1c reciprocally
regulate IRS-2 expression and insulin sensitivity in the liver
Kamagate et al., Endocrinology 2010
:
Increased
FoxO1 activity
augments the expression of insulin receptor (IR) and IR substrate
(IRS)2 , which in turn inhibits FoxO1 activity in response to reduced insulin action