◀ Back to IL2

CHAT — IL2

Text-mined interactions from Literome

Awatsuji et al., J Neurosci Res 1993 : On the other hand, IL-2 did not affect the choline acetyltransferase (ChAT) activity of striatal neurons, suggesting that this cytokine does not act as a differentiation factor for striatal cholinergic neurons
Mennicken et al., Synapse 1997 : Interleukin-2 increases choline acetyltransferase activity in septal-cell cultures ... IL-2 significantly enhanced ChAT activity in 5-day-old cultures ( 5 days in vitro ) ... At 10 ( 6 ) cells/well, IL-2 had no effect on ChAT activity ... The IL-2 induced increase in ChAT activity was significantly inhibited in the presence of an IL-2 receptor antibody ... Taken together, these results suggest that IL-2 can stimulate , at pM concentrations, ChAT activity by acting via its own receptors expressed by septal neurons