◀ Back to SREBF1
FXR2 — SREBF1
Text-mined interactions from Literome
Jiang et al., Diabetes 2007
(Diabetic Nephropathies...) :
In renal mesangial cells, overexpression of
FXR or treatment with GW4064 also
inhibited SREBP-1c and other lipogenic genes, transforming growth factor-beta, and interleukin-6, suggesting a direct role of FXR in modulating renal lipid metabolism and modulation of fibrosis and inflammation
Wang et al., American journal of physiology. Renal physiology 2009
(Fibrosis...) :
In the current study, we have determined a key
role of the
farnesoid X receptor ( FXR ) in modulating renal
SREBP-1 activity, glomerular lesions, and proteinuria
Mencarelli et al., PloS one 2010
(Atherosclerosis...) :
Natural and synthetic
FXR ligands
reduced the nuclear translocation of
SREBP1c caused by ritonavir