de Bruyn et al., J Biol Chem 2002
:
In T-lymphocytes the Ras-like small GTPase Rap1 plays an essential role in stimulus induced inside-out activation of integrin LFA-1 ( alpha ( L ) beta ( 2 ) ) and VLA-4 ( alpha ( 4 ) beta ( 1 ) ) ... These findings indicate that available levels of GTP bound Rap1 are required for the direct activation of LFA-1 and VLA-4 Schultess et al., Blood 2005
:
The Ras-like guanine-nucleotide binding protein Rap1 controls integrin alpha ( IIb ) beta3 activity and platelet aggregation
Danielewski et al., Thromb Haemost 2005
(Calcium Signaling) :
Since Rap1 controls the function of integrin alpha ( IIb ) beta3, we propose that Rap 1 inhibition might play a central role in the anti-aggregatory actions of NO/cGMP