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ADAM10 — CX3CL1

Text-mined interactions from Literome

Hundhausen et al., Blood 2003 : The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 ( fractalkine ) and regulates CX3CL1 mediated cell-cell adhesion ... Overexpression of ADAM10 in COS-7 cells enhanced constitutive cleavage of CX3CL1 and, more importantly, in murine fibroblasts deficient of ADAM10 constitutive CX3CL1 cleavage was markedly reduced ... Our data demonstrate that ADAM10 is involved in the constitutive cleavage of CX3CL1 and thereby may regulate the recruitment of monocytic cells to CX3CL1 expressing cell layers
Uchida et al., Lab Invest 2013 (MAP Kinase Signaling System...) : CX3CL1 release was suppressed by specific inhibitors of ERK, MMP, and ADAM , and ERK was associated with CX3CL1 transcription