Xie et al., Mol Reprod Dev 2010
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Benzo ( a ) pyrene causes PRKAA1/2 dependent ID2 loss in trophoblast stem cells ... Although PRKAA1/2 was activated at low BaP doses, PRKAA1/2 dependent ID2 protein loss occurred at a dose that was similar to the threshold that results in a significant decrease in TSC accumulation and decreased fraction of proliferating TSC
Xie et al., Stem Cells Dev 2013
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The AMP activated protein kinase (AMPK) mediates rapid, stress induced loss of the inhibitor of differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), and a lasting differentiation in TSC ... We propose that AMPK may be the master regulatory enzyme for mediating stress induced loss of potency as AMPK is also required for stress induced loss of Id2 in blastocysts and TSC